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Following subcutaneous injection in human studies: Bioavailability approaches 100% with subcutaneous administration Time to maximum plasma concentration (Tmax) occurs at approximately 1.0 hour (range 0.5-1.0 hours) Maximum plasma concentration (Cmax) averages 72.8 ng/mL Area under the curve (AUC) measures 276 hrng/mL The peptide exhibits relatively low plasma protein binding at 21% , allowing substantial free drug availability for central nervous system penetration

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doi: 10.1016/j.bbagrm.2018.02.001 135 ZengB

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444 For example, OT administration increases the connectivity of brain regions critical for processing socioemotional information, such as the NAc, amygdala and PFC