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Cells 6 , 45 (2017)

Data availability Data is available upon reasonable request, numerical source data for graphs in the manuscript can be found in the supplementary data file (Supplementary Source Data 1)

Metabolomics APAP-induced liver injury biomarkers summary It is well established that translation of metabolic biomarkers from animal studies to humans is challenging due to the species difference as well as the confounding factors in humans including diet, age, lifestyle, overall health, drugdrug interaction and others, all of which will influence the metabolome profile