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As the mitochondria repair and the electron transport chain stabilizes, the cells can slowly resume normal, oxygen-based ATP production

Personalized and precision treatment strategies utilizing BAPPs can enhance therapeutic effectiveness while minimizing adverse effects

The PPP shunts glucose away from ATP producing processes and towards NADPH producing pathways

It has not yet received FDA approval, so it is classified as a research compound

Using the safety and feasibility data from these first-inhuman trials demonstrating that intermittent D+Q was well tolerated in 50 subjects (NCT 02874989 and NCT 02848131), combined with the efficacy data in mouse models, we initiated a Phase I study of senolytic therapy in older adults with early-stage symptomatic AD, SToMP-AD (Senolytic Therapy to Modulate the Progression of Alzheimers Disease, NCT04063124) (107)