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MdB, SH, JV, and JC wrote sections of the manuscript

Wiercinska-Drapalo A, Jaroszewicz J, Tarasow E et al (2005) Transforming growth factor beta(1) and prostaglandin E2 concentrations are associated with bone formation markers in ulcerative colitis patients

This action, in turn, increases LDL receptor expression 25,26,27

Another metabolic pathway altered by fumarate accumulation is the PNC, where the increase of fumarate causes the reversal of adenylosuccinate lyase to form adenylosuccinate, altering de novo purine biosynthesis [19] and making cells reliant on the salvage pathway to support purine synthesis

In studies, researchers linked low levels of vitamin D to symptom flares, fatigue, poor mental function, kidney disease, osteoporosis and a greater risk of heart disease and high blood pressure (x, x, x, x, x)