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Though we did not distinguish the extent to which cysteine restriction influences these two routes of cytosolic cluster synthesis, our findings strongly reflect previous work demonstrating a sensitivity of the CIA to GSH limitation, as GSH is required in the assembly and maturation of cytosolic clusters 77,78

In PE, endothelial dysfunction primarily manifests as barrier disruption and impaired vasodilatory capacity 31,32

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Adequate glutathione levels support the livers ability to process and eliminate toxins, heavy metals, and metabolic waste products

Table 14 summarizes exemplary modified FX polypeptides provided herein