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The elevated levels of COX-2 are one more marker associated with the arbitration and progression of thermal hyperalgesia and mechanical allodynia ( via p -NF-B prompts changes to the osmolyte levels in nerves and augmented vasoconstrictors, together with thromboxane accumulation ( + - K + activity and augment the production of vasoconstrictor thromboxane ( p - NF-B pathway and elevated levels of proteins consisting of TNF- and COX-2

doi:10.3389/fpsyt.2018.00669 Morris, C.R., HamiltonReeves, J., Martindale, R.G., Sarav, M

doi: 10.3390/antiox9070644 142 LongHZZhouZWChengYLuoHYLiFJXuSGet al