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In addition to well-established cerebrovascular and inflammatory mechanisms, emerging research highlights the gut microbiota's role in shaping stroke outcomes through the MGBA, influencing neuroinflammation, BBB integrity, and neuronal recovery (Wang et al., 2023a)

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In comparison, in the high-overdose patient (D), the maximum number of necrosed cells was 1,754 out of 5,114 (34.29%) without zonation and increased to 1,876 upon applying 50% zonation (see Figure 4)

doi: 10.1038/sj.mp.4001869