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Aside from these noradrenergic facilitated effects, neurohumoral peptides such as nitric oxide (NO) and vasoactive intestinal polypeptide (VIP) also seem to act as inhibitory neurotransmitters leading to impaired intestinal motility [21]

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It has been reported that treatment with UK-5099, an inhibitor of mitochondrial pyruvate carrier (MPC), reduces the cellular GSH level by diverting glutamine metabolism from GSH synthesis in tumor cells 37

Aberrant expansion of CD177 + neutrophils promotes endothelial dysfunction in systemic lupus erythematosus via neutrophil extracellular traps