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CONFLICT OF INTEREST The authors declare there is no conflict of interest in the authorship or publication of this manuscript

An estimated five million people worldwide have some form of lupus, but most are affected by systemic lupus erythematosus (SLE), which will be the main focus of this article

Ferritin While known as an iron-storage protein, ferritin can rise as an acute-phase reactant when inflammation is high

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The major bottlenecks for this therapy include ensuring long-term survival, functional integration of transplanted mitochondria into host cells, and development of standardized, scalable protocols for mitochondrial isolation and delivery