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More specifically, if in glomerular podocytes insulin promotes glucose uptake, with an involvement in barrier permeability, in tubules it contributes to glucose reabsorption and gluconeogenesis regulation, and plays an important role in sodium homeostasis

chronic PDE3i treatment enhances mRNA expression of AC5 and AC6, while all other isoforms are expressed at levels comparable to those of DCM patients not receiving PDE3i treatment