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The most common adverse reactions reported in clinical trials were injection site reactions (erythema, pruritus, pain) occurring in approximately 8-13% of patients

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Recently, the activation of the JNK pathway by HNE has been shown to occur upstream at the protein tyrosine phosphatase SHP-1that is inhibited by HNE, which also appears to accelerate the degradation of the enzyme (Rinna and Forman, 2008)