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It is worth noting that while this hAOX metabolism was observed in this study, the half-lives of the compounds screened in human liver cytosol were high (90 minutes), and therefore further work is needed to establish the relevance of hAOX metabolism in the overall clearance of PROTAC molecules

A total of 129 metabolites were finally identified, including 82 flavonoids (mainly including liquiritin, isoliquiritin, liquiritigenin, isoliquiritigenin, glabridin, licorice chalcone A, licorice chalcone B, apiose liquiritin, formononetin, etc.), 20 terpenoids (paeoniflorin, albiflorin, benzoylpaeoniflorin, oxypaeoniflorin, glycyrrhizic acid, etc.), 10 phenolic metabolites, 7 coumarins, and 10 other metabolites

Carruthers BM, Jain AK, de Meirleir KL, Peterson DL, Klimas NG, Lerner AM, et al

Stability Acetyl L-Carnitine HCL powder exhibits good stability under appropriate conditions

E.MiyamotoS.LiebermanJ