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Its limits are specific: it gives little weight to cumulative burden in younger people, and it can understate risk in those whose LDL-C looks reassuring but whose particle number does not

The robust presence of innate immune elements at the leading edges led some to conclude that in these chronic active MS lesions, there is a switch with the innate rather than the adaptive immune system taking over to propagate the pathology (Weiner, 2008)

Studies published before 2015

The distribution of water among the body fluid compartments is shown in Figure 6-4