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All patients receiving IV Vitamin C, had a significant improvement or stability in fatigue, bowel habits, and pain symptoms (Bazzan 2018) 60 patients with newly diagnosed cancer who visited participating institutions in Japan were used for another study

This process is facilitated by the protonation of amine groups grafted onto the polymer surface within endosomes (pH 56) and lysosomes (pH 45), which possess strong proton-buffering capacity and induce rapid osmotic swelling, thereby promoting cargo release