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Strikingly, the differential methylation status of certain key genes has shown significant epigenetic changes involved in immune evasion and pathogenesis processes

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Data derived from different groups were compared by Students t test, Kruskal-Wallis test, or Mann-Whitney U test

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In addition, mitochondrial DNA (mtDNA), which can exit mitochondria via BCL-2 antagonist/ killer 1 and BCL-2-associated X, apoptosis regulator pores or via the permeability transition pore complex, is a potent activator of cyclic GMPAMP synthase, resulting in stimulator of interferon response cGAMP interactor 1 signaling and consequent synthesis of cytokines such as interferon-1, interleukin 6 (IL-6) and tumor necrosis factor (TNF), which is account for the macrophage polarization [12]