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Costa AG, Ramasawmy R, Ibiapina HN, Sampaio VS, Xbregas LA, Brasil LW, Tarrag AM, Almeida AC, Kuehn A, Vitor-Silva S, Melo GC

Identified cellular targets through which PKA activation produces a bronchodilator effect include: MLCK: Phosphorylation of myosin light chain kinase (MLCK) by cAMP-dependent protein kinase (PKA) decreases the affinity of the kinase for Ca2+ and calmodulin , resulting in a decrease in MLCK activity

The specific screening procedure is summarized in Figure 1

Agreement between rectosigmoidoscopy and colonoscopy analyses of disease activity and healing in patients with ulcerative colitis

mRNA library preparation was performed using Illumina Stranded mRNA Prep, Ligation (Illumina, #20040534) and TruSeq Stranded mRNA Library Prep (Illumina, #20020594) kits on the King Fisher FLEX system (Thermo Fisher Scientific, #18-5400620)