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ADP-ribose interacts with the Mac1 hydrophobic cleft through conserved hydrogen bonds 68

Conversely, Habif et al

Regarding the modulation of the expression of MMPs, proteins that promote the remodeling of the extracellular matrix (ECM) [59] , melatonin achieves this repressive effect by inhibiting the p38 MAPK signaling pathway through PKA, exerting a negative effect on transcription by NF-kB, and even by docking directly at the MMP-9 activation site [28,62]