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10.1016/j.phymed.2024.155468 50 DuerrschmidtN.ZabirnykO.NowickiM.RickenA.HmeidanF

Harvesting via filtration or centrifugation impacts operational costs, followed by energy-intensive drying (spray drying at 1530/kg vs freezing-drying at 50100/kg) (Seghiri et al

First identified as a potential cognitive enhancer in 1996 by Terranova and colleagues at the French pharmaceutical development firm, Sanofi, Rimonabant was found to be of interest due to its ability to reverse the inhibition of hippocampal synaptic plasticity caused by the CBR1 agonist, WIN 55,212-2

Phenobarbital 296 Patients 1 Prospective Trial [1] One prospective RCT with phenobarbital 10mg/kg vs placebo (+symptom-triggered lorazepam for both groups) showed significant decrease in both ICU admission rate and continuous lorazepam infusion use (1 single center trial, results have not been duplicated) 1 Retrospective Trial [2] Propofol 225 Patients 5 Retrospective Trials [3 7] 1 Case Series [8] 3 Case Reports [9 11] Dexmedetomidine 6 Retrospective Trials [6 7

A 1,000mg dose of standard glutathione may be less effective than a 250mg dose of a liposomal version because the latter is actually absorbed