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In one study, after a series of four to six intra-articular PPS injections into knees of human volunteers, there was a significant increase in the size of the synovial fluid hyaluronan without causing any inflammation or bleeding into the joint cavity

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139 Intraperitoneal injection of senescent cells leads to their localization in visceral adipose tissue, indicating a high susceptibility of adipose progenitor cells to senescence under obese conditions