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Vitamin B12 and Folate Status in Cognitively Healthy Older Adults and Associations with Cognitive Performance

Neto IVS, Pinto AP, Muoz VR, de Cssia Marqueti R, Pauli JR, Ropelle ER, et al

doi: 10.1038/s41586-020-2777-8, 7 BelangerM.YangJ.PetitJ

This creates a vicious cycle, where impaired waste clearance contributes to ROS buildup, which in turn promotes neuroinflammation, alters sleep architecture, and leads to further fragmentation of sleep (Gu et al., 2022