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Apoptosis typically begins several hours after the onset of cerebral ischemia and is primarily localized to the ischemic penumbra

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An enhancing effect of methylcobalamin on the proliferative response to concanavalin A (a selective T cell mitogen) and autologous B cells was also observed in human T lymphocyte cultures in vitro [39]

POS has been proposed as a probable mechanism contributing to systemic OxS, T2D progression, and vascular damage (see Figure 3) [91,92]