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A study reported that cells treated with staurosporine were less sensitive to apoptosis under severe hypoxia (0.1% oxygen) ( 2 at which HIF-1 can dimerize with ARNT, thereby increasing the transcription of anti-apoptotic genes (Piret et al., 2002)

Pharmacological Inhibition of platelet-tumor cell cross-talk prevents platelet-induced overexpression of cyclooxygenase-2 in HT29 human colon carcinoma cells

Researchers have extensively investigated on shaping the macrophage phenotype by reprogramming iron metabolism, including iron-scavenging and supply, for curing macrophage-driven diseases [232]

doi: 10.1136/bjsm.2006.034447

SAM facilitates polyamine synthesis by providing propylamine and adding a methyl group for histone methylation (Doench et al., 2003)