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Recent research has shown that rhein can alleviate changes in the renal microstructure of model rats, and decrease the expression of apoptosis-related proteins, thereby reducing cell apoptosis, and counteracting the damage caused by oxidative stress to the kidneys (184)

5.2.2 Autoimmune diseases In a clinical trial involving MS patients, intermittent energy restriction altered blood lipid factors and gut microbiota, similar to the protective changes observed in mice (124)