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The engrafted organoids show human CD31-positive endothelial structures throughout large areas of the transplanted organoid, extending into the kidney parenchyma of the mouse

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Thus, on both a metabolite and protein level it is clear that CMD led to profound alteration of the tumor microenvironment

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In the adult human brain, tau consists of six isoforms, produced by alternative mRNA splicing of the MAPT gene located on chromosome 17q21.31, and the tau gene contains 16 exons