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Interventions may include the use of mitochondrial-targeted antioxidants and regulators of mitochondrial dynamics to restore normal function and mitigate lung injury (Sheu et al., 2006)

JAMA Psychiatry 76, 893903

When ingested, these large, complex saponin molecules travel to the lower gastrointestinal tract, where the gut microbiome performs a process called deglycosylation

Similarly, in a screen of mutant KRAS lung adenocarcinoma cells, HG106 was found to specifically inhibit SLC7A11 function and decrease tumor burden in vivo via ROS induction and mitochondrial and endoplasmic reticulum dysfunction (78)