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For example, in a Parkinsons disease mouse model treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), lanosterol levels were reduced by approximately 50% in the nigrostriatal region, a key site of dopaminergic neuron loss

However, the effect is limited when used externally alone

A single blind case series of tamoxifen in seven patients with bipolar disorder (Kulkarni et al., 2006), 16 patients with mania/mixed states (Zarate et al., 2007) and 21 adults with manic/mixed states (Yildiz et al., 2008)

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Trends Cell Biol (2020) 30(6):47890