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Photomicrograph of transverse section [T.S] in the liver of Sildenafil- treated group showed loss of the normal hepatocytes structure, fatty degeneration with pyknotic nuclei (black square & black arrow), dilation of central vein (C.V) and blood sinusoids (S) with congestion (black dotted arrow) [Fig 2B]

Glutathione peroxidase 1 (GPX1) is one of the most abundant members of the GPXs family that protects cell from oxidative damage and maintains the balance of intracellular redox systems (Brigelius-Floh, 1999)

This neuroprotective effect may be mediated by the upregulation of monocyte chemoattractant protein-induced protein 1 (MCPIP1), as the neuroprotection and anti-inflammatory effect were inhibited upon knockdown of MCPIP1 using specific small interfering RNA (siRNA) (Wang M

MTP Press, Boston, 1985). Conjugated metabolites that are pharmacologically active are not often successfully developed into drugs, whereas there are many examples of active Phase I metabolites that become drugs

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