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Compared with previous reported natural CcSOD1, TAT-CcSOD1 efficiently entered HaCaT cells in a dose-dependent manner, and significantly enhanced SOD activity in cells

GULO is prone to pseudogenization in the lineages where VC is acquired through a VC-rich diet, which is likely the case of Haplorrhini primates, Passeriformes, Teleostei fish and some bats (included in the Laurasiatheria group)