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In contrast, green synthesis approaches utilizing biological entities such as plant extracts, microorganisms, and biomolecules offer environmentally responsible alternatives that maintain or enhance therapeutic efficacy while minimizing environmental impact [12,13,14]

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The dose-dependent effects of metformin on mitochondrial function underscore the importance of careful dosage management in clinical settings ( Furthermore, it is important to note that the effectiveness of metformin varies depending on the specific tissue and the dosage used ( 4 Unraveling the mechanisms behind metformin's antioxidant properties Metformin can modulate oxidative stress by inhibiting ROS production through pleiotropic actions, including AMPK modulation, mitochondrial complex I inhibition, and increased antioxidant enzyme activity

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