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Considering the fact that most of antibody-antigen interactions are needed to have similar binding time, we did not attempt to optimize it

Frontiers in Neural Circuits 12:48

In addition, a SNP analysis showed CLOCK gene T3111C polymorphism in Japanese schizophrenia patients compared to healthy controls (Takao et al., 2007), although the same polymorphism was not observed in patients with major depressive disorder (MDD) or BD in another study of the Japanese population (Kishi et al., 2011)

Andreeff M , Dembinski J, Hall BM, Studeny M, Ling X, Marini FC