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Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice. Scientific Reports (2022): 484

In contrast, DIO mice in both groups switched from WD to LD each had significantly increased Proteobacteria relative abundance (represented solely by the genus Parasutterella ) compared to both the WD and the LD controls, suggesting that Proteobacteria relative abundance may be largely influenced by stress or the differences in net energy expenditure (or associated body weight changes) caused by the diet switch

[2] Hydroxocobalamin converts cyanide to the much less toxic cyanocobalamin

Symptoms of Vitamin B12 Deficiency Vitamin B12 deficiency often develops gradually