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Approximately 510% of APAP undergoes hepatic metabolism by cytochrome CYP 2E1, as a consequence, a highly reactive and harmful metabolite known as N -acetyl-para-benzoquinone imine (NAPQI), Fig

CAFs are also involved in tumour immune evasion through interactions with MDSCs, which exert immunosuppressive functions and affect T cell proliferation, and with dendritic cells, leading to the downregulation of their HLA molecules 167,168,169

doi:10.1093/jrr/rraa137