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Lam YY, Tsai SF, Chen PC, Kuo YM, Chen YW

Vasina et al., 2009

Mice had to traverse two different beams

RIPS-1 is therefore induced by thiol-reducing agents and H 2 S

For example, drug candidates that act as electrophiles and react with Keap1 thiol groups could act on other electrophile-sensitive pathways, such as histone deacetylase enzymes