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TT genotype is associated with increased risk of: Colorectal and lung cancers Unipolar depression Adult acute lymphoblastic leukemia Ischemic stroke Cleft lip/palate Down syndrome (especially when combined with methionine synthase reductase mutations) Interestingly, the 677T allele may confer reduced susceptibility to hepatitis B virus (HBV) infection in endemic regions

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Reported side effects are generally mild and may include localized pain or redness at the injection site

Then, all mice were euthanized, and knee joints were harvested for subsequent analysis