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The menstrual cycle was recorded as regular or irregular and stratified into four phases according to the number of days after beginning menses: menstrual (16 days), follicular (714 days), luteal (1524 days), and premenstrual (25 days

ROS accumulation activates two signaling pathways, MAPK and NF-B 59 , which together inhibit collagen production by dermal fibroblasts and reduce collagen fiber density 60

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Peng DH , Tedeschi A, Herdeis L, Schaaf O, Savarese F, Rocchetti F, Popow J, Huber HJ, Wilding B, Treu M, Fuchs J, Breker J, Wunberg T, Schischlik F, Lipp J, Williams M, Chandler V, Deckard CE, Ramamoorthy V, Daniele JR, Kopetz S , Kim M, Gibbons DL, Vellano CP, Marszalek JR, Heffernan TP, McConnell D, Pearson M, Kraut N, Rudolph D