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Angiogenesis and anti-inflammatory/antioxidant signaling The preclinical literature also attributes to GHK-Cu the promotion of angiogenesis (the formation of new blood vessels, essential to feeding a healing wound), the recruitment of repair cells such as macrophages and capillary cells, and a set of anti-inflammatory and antioxidant effects

It helps skin cells regenerate, reduces pigmentation, and boosts collagen production

Observed side effects in research models include: Marked increase in appetite and hunger sensations

Importantly, the M1/M2 classification is considered an oversimplification of macrophage functional spectrum

Wang C, Wen L, Wang K, Wu R, Li M, Zhang Y, et al