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Kyo S, Sakaguchi J, Kiyono T, Shimizu Y, Maida Y, Mizumoto Y, Mori N, Nakamura M, Takakura M, Miyake K, et al

Key findings from cartilage research [7] : In vivo experiments used collagenase-induced osteoarthritis rabbit models Intra-articular AOD9604 injections enhanced cartilage regeneration Morphological assessments showed significantly improved cartilage structure Reduced degeneration scores compared to control groups Combined treatment with hyaluronic acid produced additive positive effects superior to either agent alone Chondrocyte Stimulation Studies Research suggests AOD9604 may promote differentiation of myoblasts and stimulate chondrocytes to produce extracellular matrix components [7]

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Through binding to target mRNAs, miRNAs can downregulate gene expression, effectively regulating several cellular processes, including cell differentiation, growth, proliferation, and apoptosis

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