glutathione sythesis synthetase Figure 2 from GLUTATHIONE SYNTHESIS

By degrading GSH, CHAC1 perturbs redox homeostasis and can effectively blunt the NRF2-driven cytoprotective response

J Biomed Biotechnol Ajsuvakova OP, Tinkov AA, Aschner M, Rocha JB, Michalke B, Skalnaya MG, Skalny AV, Butnariu M, Dadar M, Sarac I, Aaseth J (2020) Sulfhydryl groups as targets of mercury toxicity

initial treatment, in combination with cisplatin, of patients with malignant pleural mesothelioma whose disease is unresectable or who are otherwise not candidates for curative surgery

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