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Nowadays, in vitro study shows that JIB-04, a novel histone demethylase inhibitors targets colorectal cancer stem cells (CSC), was able to repress CSC growth, invasion, and migration to fight against colorectal cancer [82]

Some other special properties of remaining covalent inhibitors are summarized below

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AOD9604 and Safety Pharmacology Research A conventional Ames test showed no significant mutation rate increase for AOD9604 at up to 2,000 g/plate, with no clastogenic effects observed in CHO-cell chromosome aberration assays

Phase and baseline corrections, as well as metabolic identification and quantification, were performed in Chenomx NMR Suite 7.1 (Chenomx Inc., Edmonton, Canada)