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Potent inhibition of CI by IACS-010759 resulted in neurotoxicity at concentrations required for therapeutic benefit 51

Twenty microliters of a 12 Sm TG solution extracted from either the BY4741-TG or GCI-TG strain was mixed with 460 L of the mixture (50 mM TrisHCl (pH 8.0), 0.2% N , N -dimethyl casein, 13 M MDC)

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