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Ultimately, the deamidase activity of PFAS may promote tumor pathogenesis through PHDGH-mediated nucleotide supply [80]

This is the reason why chronic intake of high-calorie diets, prolonged ingestion of high fats, and obesity lead to a reduction in gastric ghrelin production and secretion (48, 49), while a low protein supply significantly increases plasma ghrelin (49) ( Figure 3 )

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In contrast, AtD14 failed to rescue the germination ability of kai2-2 mutants 13 , suggesting that D14 was not involved in germination