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It is mainly considered to be the joint between your thigh bone (femur) at the top connecting to the shin bone in the lower leg (or calf area), the tibia, providing the bottom weight-bearing portion of the joint

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These observations have led some medical professionals to believe that estrogen may play a role in causing SLE

[DOI] [PMC free article] [PubMed] [Google Scholar] 83.Chen Y., Zhang H., Liu H., Li K., Su X