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Therapeutic strategies aimed at reinforcing antioxidant pathways (such as GPX4, CoQ10, and BH4) may offer promising avenues to mitigate ferroptosis-related neurodegeneration

Additionally, combination therapy studies indicate that ITCs can sensitize tumors to conventional chemotherapy and overcome drug resistance, thereby improving therapeutic outcomes when used as adjuncts (130)

Importantly, differences in diagnostic criteria across these definitions may affect comparability among studies, cohorts, and regions

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A tumor cord model for doxorubicin delivery and dose optimization in solid tumors