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10.1016/j.biopha.2019.109670 12 CicchettiF.LacroixS.CisbaniG.ValliresN.Saint-PierreM.St-AmourI.et al (2014)

Postprandial reduction in 2,3-DPG would be expected to reduce oxygen availability to tissues and may reduce physical activity and cause sleepiness, which is a common observation following the ingestion of high-carbohydrate meals (24)