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Increasing evidence suggested that HIF plays a critical role in regulating IR, obesity, T2DM, and nonalcoholic fatty liver disease (NAFLD) ( In vitro , primary hepatocytes pretreated with TNF- were utilized to assess the effect of BBR on hepatic insulin sensitivity

In the mouse, these embryos characteristically have a diamond ring-shape appearance with a hollowed-out cavity (blastocoel) as a consequence of hydrostatic pressure generated by the trophectoderm cells cDNA clone: Double stranded DNA copy of a messenger RNA (mRNA) encoding a specific gene Conditional and/or inducible knockouts: Mice generated by the genetic manipulation of embryonic stem (ES) cells such that a specific genetic locus has been altered by the addition of recombinase recognition elements flanking the gene sequence, or region of importance, to facilitate its deletion from the genome (i.e., the generation of a null allele) in the cells of one or more defined lineages Congenic strain of mice: Strains of mice that are genetically identical except for a limited genetic region or locus