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FAK and Pyk2 activity promote TNF- and IL-1-mediated pro-inflammatory gene expression and vascular inflammation

Recently, baicalein was shown to prevent ferroptosis in erastin-treated PANC1 cells (a human pancreatic cancer cell line) by reducing ferrous iron, inhibiting GSH consumption, and inhibiting GPX4 degradation, thereby suppressing lipid peroxidation

Holm C, Kirchgessner TG, Svenson KL, Fredrikson G, Nilsson S, Miller CG, Shively JE, Heinzmann C, Sparkes RS, Mohandas T, et al

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FIGURE 1 Polyunsaturated fatty acids (PUFAs) are generally deemed to be the most predominant substrates of lipid peroxidation