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However, clinical translation has been challenging due to delivery issues and side effects

I'm generally fairly happy to trust my judgement on things

Cross-compound receptor-occupancy percentages are deliberately not compared here: occupancy (pRO) is a modeled inference, not a measurement, and Willard 2020 cautions that "calculating pRO values has caveats." Binding affinity is the measured quantity

The effects of the Tbx1 mutation on brain metabolism were analysed first by reporting the results obtained in PBS-treated Tbx1 +/ and WT brains, followed by those obtained in vB12-treated animals with the same genotypes