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[11] Without sufficient glutathione to keep that oxidative stress in check, excess amounts can impact other tissues

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Complete substitution with modified nucleotides in self-amplifying RNA suppresses the interferon response and increases potency

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In mouse forebrain, increased CREB activity due to overexpression of Calcium/calmodulin-dependent protein kinase IV (CaMKIV) leads to higher contextual fear and social recognition memory accompanied by higher long-term plasticity in hippocampus and anterior cingulate cortex (Wu et al., 2008