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To view a copy of this license, visit About this article Cite this article Lei, Y., Tang, L., Xie, Y

L., & Kovacs, E

Interestingly, copper accumulation in ATP7B -deficient hepatic cells increases the expression of PRNP through the transcription factor MTF1 [61,62,63], thus forming a positive feedback loop that amplifies copper overload under the pathological condition