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In males, fertility depends on spermatogenesis, transport, and seminal fluid factors secreted by the prostate and seminal vesicles

doi: 10.1530/EJE-21-0977 41 JekovJHnaVKoskMKrekMLikRVymazalJet al

Key accelerators include: Mitochondrial dysfunction: Leading to reduced energy output and increased reactive oxygen species (ROS)

Accordingly, novel technologies such as liquid biopsy, high-dimensional cytology, single-cell omics, metabolomics, and high-resolution imaging could be used to discover more easily detected biomarkers, bringing great convenience to drug-resistant cancer treatment